José CUEZVA, PhD

Autonomous University of Madrid, Madrid, ES

José Cuezva was born in Bilbao in 1952, graduated in Biology at Universidad del País Vasco in 1975, and completed his PhD in Biochemistry at the Universidad Autónoma de Madrid (Spain) in 1978.
Following a postdoctoral period at Case Western Reserve University in Cleveland, USA, he was appointed Associate Professor of Biochemistry and Molecular Biology at the Centro de Biología Molecular Severo Ochoa (CBMSO) from the Universidad Autónoma de Madrid (UAM) in 1983.
In 1998 he became Full Professor at the same Institution. For many years now, the research interests of his laboratory at the UAM have been the characterization of the mechanisms that control the expression and activity of the mitochondrial ATP synthase, both in development and in cancer.
The ATP synthase, which is the rotatory engine that drives the synthesis of ATP, is a main player in mitochondrial function that also forms part of the machinery involved in the execution of cell death.
More recently, the lab is also interested in the signalling pathways by which IF1, a physiological inhibitor of the ATP synthase, participates in the regulation of energy metabolism, cellular homeostasis and in the biology of cancer cells. For these purposes, they have developed a large collection of conditional tissue-specific transgenic mice that overexpress human IF1 or a constitutively active mutant version of the protein to carry out these studies in vivo.